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The non-Hodgkin lymphomas (NHL) are a heterogeneous group of lymphoproliferative malignancies with differing patterns of behavior and responses to treatment.[1] Like Hodgkin lymphoma, NHL usually originates in lymphoid tissues and can spread to other organs.NHL, however, is much less predictable than Hodgkin lymphoma and has a far greater predilection to disseminate to extranodal sites.

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Of patients with aggressive NHL, more than 50% can be cured.

The vast majority of relapses occur in the first 2 years after therapy.

Indolent NHL types have a relatively good prognosis with a median survival as long as 20 years, but they usually are not curable in advanced clinical stages.[3] Early-stage (stage I and stage II) indolent NHL can be effectively treated with radiation therapy alone.

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